HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-tert-Butylethylamine → 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-tert-Butylethylamine | HCID 521156 | — |
| Reactant | 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid | HCID 90203674 | — |
| Product | 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid tert-butyl-ethyl-amide | HCID 90204085 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 23b, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and N-ethyl-2-methylpropan-2-amine (CAN 4432-77-3) as starting materials and isolated (50 mg, 47%) as a light yellow solid; MS (ESI, m/z): 345.7 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-96446e79cf2a45d7b81924bdf8d4b8e1 |
| Source note | uspto-grants-2016_08 |