2-Cyclopropyl-1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine → HCID 90203874, compound

HRID 1480189Notes

Reaction equation

HRID 1480189 reaction equation
[OH:1][C:2]1([C:6]2[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:8][C:9]([C:12]([OH:14])=O)=[N:10][CH:11]=2)[CH2:5][O:4][CH2:3]1.[CH:21]1([CH2:24][C:25]([NH2:33])([CH3:32])[C:26]2[N:30]=[C:29]([CH3:31])[O:28][N:27]=2)[CH2:23][CH2:22]1>>[CH:21]1([CH2:24][C:25]([NH:33][C:12]([C:9]2[CH:8]=[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])[C:6]([C:2]3([OH:1])[CH2:3][O:4][CH2:5]3)=[CH:11][N:10]=2)=[O:14])([C:26]2[N:30]=[C:29]([CH3:31])[O:28][N:27]=2)[CH3:32])[CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 710877912-Cyclopropyl-1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamineHCID 90203890HCID 90203890, compound

Product 1

HCID 90203874HCID 90203874, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-(3-hydroxyoxetan-3-yl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (Example 112d) and 2-Cyclopropyl-1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (example 66e) as starting materials and isolated (37 mg, 47%); MS (ESI, m/z): 457.5 (M+H+).

Workup

  1. customisolated (37 mg, 47%)

Sources & evidence

ORD record
ord-7d1b303a72a2409898e200f77e106076
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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