反应详情

The title compound was synthesized in analogy to Example 112e, using 5-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid (example 142b) and 1-Cyclopropyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine (CAN1155536-64-3) as starting materials and the mixture of epimers was isolated (72 mg, 40%). The mixture of epimers was separated into its epimers by preparative chiral HPLC (Chiralpak AD, ethanol/heptane) and the title compound was the first epimer collected and isolated as colorless oil; MS (ESI, m/z): 459.5 (M+H+).

1. additionthe mixture of epimers
2. customwas isolated (72 mg, 40%)
3. additionThe mixture of epimers
4. customwas separated into its epimers by preparative chiral HPLC (Chiralpak AD, ethanol/heptane)
5. customcollected
6. customisolated as colorless oil