2,2-Dimethyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)propan-1-amine → N-[2,2-dimethyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)propyl]-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamide

HRID 1480248Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1480248
[F:1][C:2]1([C:6]2[C:7]([O:15][C@@H:16]([CH3:21])[C:17]([F:20])([F:19])[F:18])=[CH:8][C:9]([C:12](O)=[O:13])=[N:10][CH:11]=2)[CH2:5][O:4][CH2:3]1.[CH3:22][C:23]([CH3:33])([CH3:32])[CH:24]([C:26]1[O:27][C:28]([CH3:31])=[N:29][N:30]=1)[NH2:25]>>[CH3:22][C:23]([CH3:33])([CH3:32])[CH:24]([NH:25][C:12]([C:9]1[CH:8]=[C:7]([O:15][C@@H:16]([CH3:21])[C:17]([F:20])([F:19])[F:18])[C:6]([C:2]2([F:1])[CH2:3][O:4][CH2:5]2)=[CH:11][N:10]=1)=[O:13])[C:26]1[O:27][C:28]([CH3:31])=[N:29][N:30]=1

Komponenten

3

Edukt 2

HCID 689184512,2-Dimethyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)propan-1-amineHCID 902149505-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid

Produkt 1

HCID 90214972N-[2,2-dimethyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)propyl]-5-(3-fluorooxetan-3-yl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxypyridine-2-carboxamide

Versuchsvorschrift

The title compound was synthesized in analogy to Example 112e, using 5-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid (example 142b) and 2,2-dimethyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)propan-1-amine (example 174b) as starting materials and isolated (70 mg, 47%); MS (ESI, m/z): 461.5 (M+H+).

Aufarbeitung

  1. customisolated (70 mg, 47%)

Quellen und Nachweise

ORD-Eintrag
ord-a39d206962aa4babbe73ba360f52820a
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409866B2

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