Azetidine → HCID 90204537, compound

HRID 1480253Notes

Reaction equation

HRID 1480253 reaction equation
[CH:1]1([C:4]2[C:5]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[CH:6][C:7]([C:10]([NH:12][C:13]([C:18]3[N:22]=[C:21]([CH3:23])[O:20][N:19]=3)([CH3:17])[C:14](O)=[O:15])=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH:30]1[CH2:33][CH2:32][CH2:31]1>>[N:30]1([C:14](=[O:15])[C:13]([NH:12][C:10]([C:7]2[CH:6]=[C:5]([O:24][CH2:25][C:26]([F:27])([F:28])[F:29])[C:4]([CH:1]3[CH2:2][CH2:3]3)=[CH:9][N:8]=2)=[O:11])([C:18]2[N:22]=[C:21]([CH3:23])[O:20][N:19]=2)[CH3:17])[CH2:33][CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 10422AzetidineHCID 90203702HCID 90203702, compound

Product 1

HCID 90204537HCID 90204537, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 2-[[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]-2-(5-methyl-1,2,4-oxadiazol-3-yl)propanoic acid (example 147c) and azetidine (CAN 503-29-7) as starting materials and isolated (23 mg, 51%); MS (ESI, m/z): 454.5 (M+H+).

Workup

  1. customisolated (23 mg, 51%)

Sources & evidence

ORD record
ord-b13cd391d8be4222a93334551f1f9c52
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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