Ammonium Chloride → HCID 90203677, compound

HRID 1480260Notes

Reaction equation

HRID 1480260 reaction equation
[CH:1]1([CH2:4][C:5]([NH:10][C:11]([C:13]2[CH:18]=[C:17]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])[C:16]([CH:25]3[CH2:27][CH2:26]3)=[CH:15][N:14]=2)=[O:12])([CH3:9])[C:6]([OH:8])=O)[CH2:3][CH2:2]1.[Cl-].[NH4+:29]>>[NH2:29][C:6](=[O:8])[C:5]([NH:10][C:11]([C:13]1[CH:18]=[C:17]([O:19][CH2:20][C:21]([F:23])([F:24])[F:22])[C:16]([CH:25]2[CH2:27][CH2:26]2)=[CH:15][N:14]=1)=[O:12])([CH3:9])[CH2:4][CH:1]1[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 25517Ammonium ChlorideHCID 90203469HCID 90203469, compound

Product 1

HCID 90203677HCID 90203677, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 3-cyclopropyl-2-[[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]-2-methyl-propanoic acid (example 186d) and ammonium chloride as starting materials and isolated (16 mg, 32%); MS (ESI, m/z): 386.6 (M+H+).

Workup

  1. customisolated (16 mg, 32%)

Sources & evidence

ORD record
ord-6a8ab1f44ba7407097f045287275f362
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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