HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(5-Methyl-1,3,4-oxadiazol-2-yl)-1-(oxetan-3-yl)propan-2-amine → 5-cyclopropyl-N-[2-(5-methyl-1,3,4-oxadiazol-2-yl)-1-(oxetan-3-yl)propan-2-yl]-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(5-Methyl-1,3,4-oxadiazol-2-yl)-1-(oxetan-3-yl)propan-2-amine | HCID 90203248 | — |
| Reactant | 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid | HCID 90203674 | — |
| Product | 5-cyclopropyl-N-[2-(5-methyl-1,3,4-oxadiazol-2-yl)-1-(oxetan-3-yl)propan-2-yl]-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide | HCID 90204337 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 2-(5-methyl-1,3,4-oxadiazol-2-yl)-1-(oxetan-3-yl)propan-2-amine (example 190c) as starting materials and isolated (35 mg, 21%); MS (ESI, m/z): 441.5 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-edd4c12a60f448a5b38b0045b4b9a1f2 |
| Source note | uspto-grants-2016_08 |