Ammonium Chloride → HCID 76281194, compound

HRID 1480267Notes

Reaction equation

HRID 1480267 reaction equation
[CH:1]1([C:4]2[C:5]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[CH:6][C:7]([C:10]([NH:12][CH:13]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:14](O)=[O:15])=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[Cl-].[NH4+:28]>>[NH2:28][C:14](=[O:15])[CH:13]([NH:12][C:10]([C:7]1[CH:6]=[C:5]([O:21][CH2:22][C:23]([F:25])([F:24])[F:26])[C:4]([CH:1]2[CH2:3][CH2:2]2)=[CH:9][N:8]=1)=[O:11])[C:17]([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 25517Ammonium ChlorideHCID 902039752-[[5-Cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoic acid

Product 1

HCID 76281194HCID 76281194, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 2-[[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoic acid (Example 194b) and ammonium chloride as starting materials and isolated (490 mg, 92%); MS (ESI, m/z): 374.5 (M+H+).

Workup

  1. customisolated (490 mg, 92%)

Sources & evidence

ORD record
ord-d8e0559de63346fc9a93748b1d5edc57
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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