Azetidine → HCID 76281460, compound

HRID 1480269Notes

Reaction equation

HRID 1480269 reaction equation
[CH:1]1([C:4]2[C:5]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[CH:6][C:7]([C:10]([NH:12][CH:13]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:14](O)=[O:15])=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH:27]1[CH2:30][CH2:29][CH2:28]1.C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.[Mg+2]>>[N:27]1([C:14](=[O:15])[CH:13]([NH:12][C:10]([C:7]2[CH:6]=[C:5]([O:21][CH2:22][C:23]([F:24])([F:26])[F:25])[C:4]([CH:1]3[CH2:3][CH2:2]3)=[CH:9][N:8]=2)=[O:11])[C:17]([CH3:19])([CH3:20])[CH3:18])[CH2:30][CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 10422AzetidineHCID 11418570Magnesium gluconate anhydrousHCID 902039752-[[5-Cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoic acid

Product 1

HCID 76281460HCID 76281460, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 2-[[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoic acid (Example 194b) and azetidine (CAN 503-29-7) as starting materials and isolated (29 mg, 54%); MS (ESI, m/z): 414.6 (M+H+).

Workup

  1. customisolated (29 mg, 54%)

Sources & evidence

ORD record
ord-802c016f0ad7463f806ebd6abe289108
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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