Oxalate → HCID 90204713, compound

HRID 1480271Notes

Reaction equation

HRID 1480271 reaction equation
[CH:1]1([C:4]2[C:5]([O:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[CH:6][C:7]([C:10]([NH:12][CH:13]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:14](O)=[O:15])=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH:27]1[C:30]2([CH2:33][O:32][CH2:31]2)[CH2:29][CH2:28]1.C([O-])(=O)C([O-])=O>>[CH:1]1([C:4]2[C:5]([O:21][CH2:22][C:23]([F:24])([F:26])[F:25])=[CH:6][C:7]([C:10]([NH:12][CH:13]([C:17]([CH3:18])([CH3:19])[CH3:20])[C:14]([N:27]3[C:30]4([CH2:33][O:32][CH2:31]4)[CH2:29][CH2:28]3)=[O:15])=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 71081OxalateHCID 547591466-Oxa-1-azaspiro(3.3)heptaneHCID 90203975HCID 90203975, compound

Product 1

HCID 90204713HCID 90204713, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 2-[[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoic acid (Example 194b) and 6-Oxa-1-azaspiro[3.3]heptane, ethanedioate (1:2) (CAN 1380571-72-1) as starting materials and isolated (27 mg, 46%); MS (ESI, m/z): 456.6 (M+H+).

Workup

  1. customisolated (27 mg, 46%)

Sources & evidence

ORD record
ord-3e51573a6098489aad7258d3bf071a33
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

Loading…