3-Methyl-3-oxetanemethanol → HCID 90203924, compound

HRID 1480283Notes

Reaction equation

HRID 1480283 reaction equation
Cl[C:2]1[C:7]([CH:8]2[CH2:10][CH2:9]2)=[CH:6][N:5]=[C:4]([C:11]#[N:12])[CH:3]=1.[CH3:13][C:14]1([CH2:18][OH:19])[CH2:17][O:16][CH2:15]1>>[CH:8]1([C:7]2[C:2]([O:19][CH2:18][C:14]3([CH3:13])[CH2:17][O:16][CH2:15]3)=[CH:3][C:4]([C:11]#[N:12])=[N:5][CH:6]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 1378373-Methyl-3-oxetanemethanolHCID 90203632HCID 90203632, compound

Product 1

HCID 90203924HCID 90203924, compound

Procedure

The title compound was synthesized in analogy to Example 123c, using 4-chloro-5-cyclopropyl-pyridine-2-carbonitrile (example 215b), (3-methyloxetan-3-yl)methanol (CAN 3143-02-0) as starting materials and isolated (1.73 g, 83%); MS (ESI, m/z): 245.5 (M+H+).

Workup

  1. customisolated (1.73 g, 83%)

Sources & evidence

ORD record
ord-664ffa156ade4fda8436c295634867cc
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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