HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-(3-Aminooxetan-3-yl)acetamide → N-[3-(2-amino-2-oxoethyl)oxetan-3-yl]-5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-(3-Aminooxetan-3-yl)acetamide | HCID 75537524 | — |
| Edukt | 5-(3,3-Difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)picolinic acid | HCID 90204045 | — |
| Produkt | N-[3-(2-amino-2-oxoethyl)oxetan-3-yl]-5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide | HCID 90203732 | — |
Reaktionsschritte
The title compound was synthesized in analogy to Example 112e, using 5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (Example 223b) and 2-(3-Amino-oxetan-3-yl)-acetamide (CAN 1417638-25-5) as starting material and isolated (42 mg, 31%); MS (ESI, m/z): 425.5 (M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09409866B2 |
| Quelldatensatz | uspto-grants-2016_08 |
| ORD ID | ord-22806a90b68a4e7ba35f559782219182 |
| Quellennotiz | uspto-grants-2016_08 |