Methylamine hydrochloride → HCID 90203443, compound

HRID 1480294Notes

Reaction equation

HRID 1480294 reaction equation
[CH:1]1([C:4]([NH:10][C:11]([C:13]2[CH:18]=[C:17]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])[C:16]([CH:25]3[CH2:27][CH2:26]3)=[CH:15][N:14]=2)=[O:12])([CH3:9])[CH2:5][C:6]([OH:8])=O)[CH2:3][CH2:2]1.Cl.[CH3:29][NH2:30]>>[CH:25]1([C:16]2[C:17]([O:19][CH2:20][C:21]([F:22])([F:24])[F:23])=[CH:18][C:13]([C:11]([NH:10][C:4]([CH:1]3[CH2:3][CH2:2]3)([CH2:5][C:6]([NH:30][CH3:29])=[O:8])[CH3:9])=[O:12])=[N:14][CH:15]=2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 6364545Methylamine hydrochlorideHCID 90205174HCID 90205174, compound

Product 1

HCID 90203443HCID 90203443, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 3-cyclopropyl-3-[[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]butanoic acid (Example 229d) and methanamine hydrochloride as starting materials and isolated (90 mg, 58%); MS (ESI, m/z): 400.5 (M+H+).

Workup

  1. customisolated (90 mg, 58%)

Sources & evidence

ORD record
ord-e68fdfb1180b44e0b120909ce1f1b972
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

Loading…