Ammonium Chloride → HCID 90204089, compound

HRID 1480295Notes

Reaction equation

[CH:1]1([C:4]([NH:10][C:11]([C:13]2[CH:18]=[C:17]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])[C:16]([CH:25]3[CH2:27][CH2:26]3)=[CH:15][N:14]=2)=[O:12])([CH3:9])[CH2:5][C:6]([OH:8])=O)[CH2:3][CH2:2]1.[Cl-].[NH4+:29]>>[NH2:29][C:6](=[O:8])[CH2:5][C:4]([NH:10][C:11]([C:13]1[CH:18]=[C:17]([O:19][CH2:20][C:21]([F:22])([F:23])[F:24])[C:16]([CH:25]2[CH2:26][CH2:27]2)=[CH:15][N:14]=1)=[O:12])([CH:1]1[CH2:2][CH2:3]1)[CH3:9]

Participants

Reactant 2

HCID 25517Ammonium Chloride

HCID 90205174HCID 90205174, compound

Product 1

HCID 90204089HCID 90204089, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 3-cyclopropyl-3-[[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]butanoic acid (Example 229d) and ammonium chloride as starting materials and isolated (72 mg, 48%); MS (ESI, m/z): 386.6 (M+H+).

Workup

customisolated (72 mg, 48%)

Sources & evidence

ORD record: ord-dbafb4dfcf794967b878edb1a66f4b41
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09409866B2

Reaction notes

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