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HCID 84107086、化合物 → 5-(3,3-difluoroazetidin-1-yl)-N-[3-[2-(methylamino)-2-oxoethyl]oxetan-3-yl]-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | HCID 84107086 | HCID 84107086 | — |
| 反応物 | 5-(3,3-Difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)picolinic acid | HCID 90204045 | — |
| 生成物 | 5-(3,3-difluoroazetidin-1-yl)-N-[3-[2-(methylamino)-2-oxoethyl]oxetan-3-yl]-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide | HCID 90203281 | — |
反応手順
The title compound was synthesized in analogy to Example 112e, using 5-(3,3-difluoroazetidin-1-yl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (Example 223b) and 2-(3-aminooxetan-3-yl)-N-methyl-acetamide (example 231a) as starting materials and isolated (25 mg, 43%); MS (ESI, m/z): 439.5 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09409866B2 |
| 出典データセット | uspto-grants-2016_08 |
| ORD ID | ord-9fa5914a37124348872ad495df0ba254 |
| 出典メモ | uspto-grants-2016_08 |