HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine hydrochloride → tert-butyl N-[2-hydroxy-2-methyl-1-(methylcarbamoyl)propyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | N-Boc-(+-)-2-amino-3-hydroxy-3-methylbutanoic acid | HCID 13756005 | — |
| Product | tert-butyl N-[2-hydroxy-2-methyl-1-(methylcarbamoyl)propyl]carbamate | HCID 90203567 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 2-tert-Butoxycarbonylamino-3-hydroxy-3-methyl-butyric acid (CAN 105504-72-1) and methanamine hydrochloride as starting materials and isolated (486 mg, 38%); MS (ESI, m/z): 247.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-4d8a2040576f40389348dad3e3507555 |
| Source note | uspto-grants-2016_08 |