Methylamine hydrochloride → HCID 90203657, compound

HRID 1480307Notes

Reaction equation

[CH:1]1([C:4]([NH:10][C:11]([C:13]2[CH:18]=[C:17]([O:19][C@@H:20]([CH3:25])[C:21]([F:24])([F:23])[F:22])[C:16]([CH:26]3[CH2:28][CH2:27]3)=[CH:15][N:14]=2)=[O:12])([CH3:9])[CH2:5][C:6]([OH:8])=O)[CH2:3][CH2:2]1.Cl.[CH3:30][NH2:31]>>[CH:26]1([C:16]2[C:17]([O:19][C@@H:20]([CH3:25])[C:21]([F:23])([F:22])[F:24])=[CH:18][C:13]([C:11]([NH:10][C:4]([CH:1]3[CH2:2][CH2:3]3)([CH2:5][C:6]([NH:31][CH3:30])=[O:8])[CH3:9])=[O:12])=[N:14][CH:15]=2)[CH2:27][CH2:28]1

Participants

Reactant 2

HCID 6364545Methylamine hydrochloride

HCID 118539971HCID 118539971, compound

Product 1

HCID 90203657HCID 90203657, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 3-cyclopropyl-3-[[5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carbonyl]amino]butanoic acid (example 247b) and methanamine hydrochloride as starting materials and isolated (180 mg, 83%); MS (ESI, m/z): 414.2 (M+H+).

Workup

customisolated (180 mg, 83%)

Sources & evidence

ORD record: ord-649df81d5fca4e8cb521b5dee1674be5
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09409866B2

Reaction notes

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