Ammonium Chloride → HCID 90204154, compound

HRID 1480308Notes

Reaction equation

HRID 1480308 reaction equation
[CH:1]1([C:4]([NH:10][C:11]([C:13]2[CH:18]=[C:17]([O:19][C@@H:20]([CH3:25])[C:21]([F:24])([F:23])[F:22])[C:16]([CH:26]3[CH2:28][CH2:27]3)=[CH:15][N:14]=2)=[O:12])([CH3:9])[CH2:5][C:6](O)=[O:7])[CH2:3][CH2:2]1.[Cl-].[NH4+:30]>>[NH2:30][C:6](=[O:7])[CH2:5][C:4]([NH:10][C:11]([C:13]1[CH:18]=[C:17]([O:19][C@@H:20]([CH3:25])[C:21]([F:23])([F:24])[F:22])[C:16]([CH:26]2[CH2:27][CH2:28]2)=[CH:15][N:14]=1)=[O:12])([CH:1]1[CH2:2][CH2:3]1)[CH3:9]

Participants

3

Reactant 2

HCID 25517Ammonium ChlorideHCID 118539971HCID 118539971, compound

Product 1

HCID 90204154HCID 90204154, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 3-cyclopropyl-3-[[5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carbonyl]amino]butanoic acid (example 247b) and ammonium chloride as starting materials and isolated (150 mg, 72%); MS (ESI, m/z): 400.2 (M+H+).

Workup

  1. customisolated (150 mg, 72%)

Sources & evidence

ORD record
ord-4ebd6996f6414de6968e130d9db9119c
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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