HCID 90204553, compound → HCID 90214939, compound

HRID 1480311Notes

Reaction equation

HRID 1480311 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][C@@H:14]([CH3:19])[C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH2:20][CH:21]([C:24]1([CH3:28])[CH2:27][O:26][CH2:25]1)[C:22]#[N:23]>>[C:22]([CH:21]([C:24]1([CH3:28])[CH2:27][O:26][CH2:25]1)[NH:20][C:10]([C:7]1[CH:6]=[C:5]([O:13][C@@H:14]([CH3:19])[C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])#[N:23]

Participants

3

Reactant 2

HCID 90204553HCID 90204553, compoundHCID 902045735-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 90214939HCID 90214939, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (example 68a) and 2-amino-2-(3-methyloxetan-3-yl)acetonitrile (example 251b) as starting materials and isolated (180 mg, 83%); MS (ESI, m/z): 384.6 (M+H+).

Workup

  1. customisolated (180 mg, 83%)

Sources & evidence

ORD record
ord-ad9063c58a084df9929b6e2fd97e034c
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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