HCID 90204562, compound → HCID 90203659, compound

HRID 1480315Notes

Reaction equation

HRID 1480315 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][C@@H:14]([CH3:19])[C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:20][C:21]1[O:25][N:24]=[C:23]([CH:26]([C:28]2([CH3:32])[CH2:31][O:30][CH2:29]2)[NH2:27])[N:22]=1>>[CH:1]1([C:4]2[C:5]([O:13][C@@H:14]([CH3:19])[C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([NH:27][CH:26]([C:23]3[N:22]=[C:21]([CH3:20])[O:25][N:24]=3)[C:28]3([CH3:32])[CH2:31][O:30][CH2:29]3)=[O:12])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 90204562HCID 90204562, compoundHCID 902045735-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 90203659HCID 90203659, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (example 68a) and (5-methyl-1,2,4-oxadiazol-3-yl)-(3-methyloxetan-3-yl)methanamine (example 254b) as starting materials and isolated (47 mg, 55%); MS (ESI, m/z): 441.3 (M+H+).

Workup

  1. customisolated (47 mg, 55%)

Sources & evidence

ORD record
ord-6eeef550e4114e6fa6c9008ce7e11d33
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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