HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-3-cyclopropylbutanamide → N-(3-amino-1-cyclopropyl-1-methyl-3-oxo-propyl)-5-cyclopropyl-4-(2,2-difluoroethoxy)pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-3-cyclopropylbutanamide | HCID 83681810 | — |
| Reactant | 5-Cyclopropyl-4-(2,2-difluoroethoxy)pyridine-2-carboxylic acid | HCID 90203530 | — |
| Product | N-(3-amino-1-cyclopropyl-1-methyl-3-oxo-propyl)-5-cyclopropyl-4-(2,2-difluoroethoxy)pyridine-2-carboxamide | HCID 90203668 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 5-cyclopropyl-4-(2,2-difluoroethoxy)pyridine-2-carboxylic acid (example 145d) and 3-amino-3-cyclopropyl-butanamide (example 270c) as starting materials and isolated (55 mg, 52%) as a racemate; MS (ESI, m/z): 368.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-670b63ac75cc4025beb30ed7ec6ee02b |
| Source note | uspto-grants-2016_08 |