HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyclopropyl-4-(2,2-difluoroethoxy)pyridine-2-carboxylic acid → N-[3-(2-amino-2-oxoethyl)-1,1-dioxothietan-3-yl]-5-cyclopropyl-4-(2,2-difluoroethoxy)pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyclopropyl-4-(2,2-difluoroethoxy)pyridine-2-carboxylic acid | HCID 90203530 | — |
| Reactant | 2-(3-Amino-1,1-dioxo-thietan-3-yl)acetamide | HCID 90213830 | — |
| Product | N-[3-(2-amino-2-oxoethyl)-1,1-dioxothietan-3-yl]-5-cyclopropyl-4-(2,2-difluoroethoxy)pyridine-2-carboxamide | HCID 90214988 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 5-cyclopropyl-4-(2,2-difluoroethoxy)pyridine-2-carboxylic acid (example 145d) and 2-(3-amino-1,1-dioxo-thietan-3-yl)acetamide (example 160d) as starting materials and isolated (51 mg, 59%); MS (ESI, m/z): 404.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-395fda69e26b45828be35cc277ec63bc |
| Source note | uspto-grants-2016_08 |