HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 5-cyclopropyl-4-(2-fluoroethoxy)-N-[2-(5-methyl-1,2,4-oxadiazol-3-yl)-1-methylsulfonylpropan-2-yl]pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 5-Cyclopropyl-4-(2-fluoroethoxy)pyridine-2-carboxylic acid | HCID 90203352 | — |
| Reactant | 2-(5-Methyl-1,2,4-oxadiazol-3-yl)-1-methylsulfonyl-propan-2-amine | HCID 90203430 | — |
| Product | 5-cyclopropyl-4-(2-fluoroethoxy)-N-[2-(5-methyl-1,2,4-oxadiazol-3-yl)-1-methylsulfonylpropan-2-yl]pyridine-2-carboxamide | HCID 90203517 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 5-cyclopropyl-4-(2-fluoroethoxy)pyridine-2-carboxylic acid (example 146b) and 2-(5-methyl-1,2,4-oxadiazol-3-yl)-1-methylsulfonyl-propan-2-amine;hydrobromide (enantiomer B) (example 125b) as starting materials and isolated (56 mg, 59%); MS (ESI, m/z): 427.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-a6a7df25585c42cabb7cf2984663f101 |
| Source note | uspto-grants-2016_08 |