HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1480334Generated: October 30, 2026
Methanol → 2-(3-amino-1,1-dioxo-thietan-3-yl)-N-methyl-acetamide
https://huagongshe.com/reaction/1480334
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Ethyl (3-amino-1,1-dioxido-3-thietanyl)acetate | HCID 90202743 | — |
| Product | 2-(3-amino-1,1-dioxo-thietan-3-yl)-N-methyl-acetamide | HCID 90214951 | 99% |
Reaction Steps
ethyl 2-(3-amino-1,1-dioxo-thietan-3-yl)acetate (example 160c, 548 mg, 2.64 mmole) was dissolved in a solution 2.0M of methylamine in methanol (19.8 mL, 39.7 mmole) and the reaction mixture was stirred at 45° C. overnight. Removal of volatiles in vacuo yielded the title compound (505 mg, 99%) as crude light brown oil which was used without any further purification; MS (ESI, m/z): 193.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09409866B2 |
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| Source dataset | uspto-grants-2016_08 |
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| ORD ID | ord-9fc7c4fea7004a0c9d0b15e5f1b5e251 |
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| Source note | uspto-grants-2016_08 |
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