HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid → 5-cyclopropyl-N-[3-[2-(methylamino)-2-oxoethyl]-1,1-dioxothietan-3-yl]-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid | HCID 90203674 | — |
| Reactant | 2-(3-amino-1,1-dioxo-thietan-3-yl)-N-methyl-acetamide | HCID 90214951 | — |
| Product | 5-cyclopropyl-N-[3-[2-(methylamino)-2-oxoethyl]-1,1-dioxothietan-3-yl]-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide | HCID 90214991 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example 48c) and 2-(3-amino-1,1-dioxo-thietan-3-yl)-N-methyl-acetamide (example 282a) as starting materials and isolated (56 mg, 76%); MS (ESI, m/z): 436.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-95d33ce38d1d4fa6ba83a6556614d476 |
| Source note | uspto-grants-2016_08 |