HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinic acid → N-[3-(2-amino-2-oxoethyl)-1,1-dioxothietan-3-yl]-5-cyclopropyl-4-[1-fluoropropan-2-yl]oxypyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinic acid | HCID 90204044 | — |
| Reactant | 2-(3-Amino-1,1-dioxo-thietan-3-yl)acetamide | HCID 90213830 | — |
| Product | N-[3-(2-amino-2-oxoethyl)-1,1-dioxothietan-3-yl]-5-cyclopropyl-4-[1-fluoropropan-2-yl]oxypyridine-2-carboxamide | HCID 90214982 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 5-cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinic acid (enantiomer B) (example 289b) and 2-(3-amino-1,1-dioxo-thietan-3-yl)acetamide (example 160d) as starting materials and isolated (33.8 mg, 51%); MS (ESI, m/z): 400.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-81b0685c600740d890161552f43cce03 |
| Source note | uspto-grants-2016_08 |