HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-3-cyclopropylbutanamide → N-(4-amino-2-cyclopropyl-4-oxobutan-2-yl)-5-cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-3-cyclopropylbutanamide | HCID 83681810 | — |
| Reactant | 5-Cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinic acid | HCID 90204044 | — |
| Product | N-(4-amino-2-cyclopropyl-4-oxobutan-2-yl)-5-cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinamide | HCID 90204486 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 5-cyclopropyl-4-(1-fluoropropan-2-yloxy)picolinic acid (enantiomer B) (example 289b) and 3-amino-3-cyclopropyl-butanamide (example 270c) as starting materials and isolated (85.4 mg, 80%); MS (ESI, m/z): 364.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-33556ff766874bf79c96fb17c25e87d9 |
| Source note | uspto-grants-2016_08 |