HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-3-cyclopropylbutanamide → N-(4-amino-2-cyclopropyl-4-oxobutan-2-yl)-5-(1-fluorocyclobutyl)-4-(2,2,2-trifluoroethoxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-3-cyclopropylbutanamide | HCID 83681810 | — |
| Reactant | 5-(1-Fluorocyclobutyl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid | HCID 90203492 | — |
| Product | N-(4-amino-2-cyclopropyl-4-oxobutan-2-yl)-5-(1-fluorocyclobutyl)-4-(2,2,2-trifluoroethoxy)picolinamide | HCID 90203670 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 5-(1-fluorocyclobutyl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (example 285a) and 3-amino-3-cyclopropyl-butanamide (example 270c) as starting materials and isolated (55 mg, 49%); MS (ESI, m/z): 418.4 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-c7b65827be7f4c2088eaca65ff46891e |
| Source note | uspto-grants-2016_08 |