HCID 90204251, compound → HCID 90215003, compound

HRID 1480361Notes

Reaction equation

HRID 1480361 reaction equation
[F:1][CH:2]([F:19])[CH2:3][O:4][C:5]1[C:10]([C:11]2([F:15])[CH2:14][CH2:13][CH2:12]2)=[CH:9][N:8]=[C:7]([C:16]([OH:18])=O)[CH:6]=1.[NH2:20][C:21]1([CH2:27][C:28]([NH2:30])=[O:29])[CH2:24][S:23](=[O:26])(=[O:25])[CH2:22]1>>[NH2:30][C:28](=[O:29])[CH2:27][C:21]1([NH:20][C:16]([C:7]2[CH:6]=[C:5]([O:4][CH2:3][CH:2]([F:1])[F:19])[C:10]([C:11]3([F:15])[CH2:12][CH2:13][CH2:14]3)=[CH:9][N:8]=2)=[O:18])[CH2:22][S:23](=[O:25])(=[O:26])[CH2:24]1

Participants

3

Reactant 2

HCID 90204251HCID 90204251, compoundHCID 902138302-(3-Amino-1,1-dioxo-thietan-3-yl)acetamide

Product 1

HCID 90215003HCID 90215003, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 4-(2,2-difluoroethoxy)-5-(1-fluorocyclobutyl)pyridine-2-carboxylic acid (example 308b) and 2-(3-amino-1,1-dioxo-thietan-3-yl)acetamide (example 160d) as starting materials and isolated (11.5 mg, 14%); MS (ESI, m/z): 436.3 (M+H+).

Workup

  1. customisolated (11.5 mg, 14%)

Sources & evidence

ORD record
ord-4a9bb1d313ac42c5b3dcd341f32ddccd
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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