反应详情

2-Methoxythiazole-5-carboxylic acid (step 1) (45.5 mg, 0.286 mmol) was solubilised in MeOH (2 ml) and treated with 5.4M NaOMe in MeOH (212 μl, 1.143 mmol) followed by 2M NaOH (572 μl, 1.143 mmol). The reaction mixture was refluxed overnight and after cooling to RT, the solvent was evaporated under reduced pressure. The residue was acidified with 6M aqueous hydrochloric acid and aqueous layer extracted with EtOAc. The organics were combined and dried over MgSO4 (anh) filtered and evaporated under reduced pressure resulting in a pale yellow solid.

1. temperatureThe reaction mixture was refluxed overnight
2. customthe solvent was evaporated under reduced pressure
3. extractionextracted with EtOAc
4. dry with materialdried over MgSO4 (anh)
5. filtrationfiltered
6. customevaporated under reduced pressure
7. customresulting in a pale yellow solid