4-(1-Benzyl-1H-1,2,3-triazol-4-yl)butanoic acid → HCID 178525383, compound

HRID 1480394Notes

Reaction equation

HRID 1480394 reaction equation
C([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[N:10]=[N:9]1)C1C=CC=CC=1>CCO.[Pd]>[NH:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[N:10]=[N:9]1

Participants

4

Reactant 1

HCID 247519584-(1-Benzyl-1H-1,2,3-triazol-4-yl)butanoic acid

Product 1

HCID 178525383HCID 178525383, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-(1-Benzyl-1H-1,2,3-triazol-4-yl)butanoic acid (step 3) (5.34 g, 21.77 mmol) was dissolved in EtOH (435 ml) and re-circulated through a 75 mm 10% Pd/C catalyst cartridge and hydrogenated using the H-Cube continuous flow hydrogenation at 60° C., 30 bar pressure for 72 hr. The reaction mixture was evaporated under reduced pressure to afford the title compound;

Workup

  1. customat 60° C.
  2. customThe reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-0e69b3aa35b94d67b8d90cd797e0b362
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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