tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylate → HCID 178451875, compound

HRID 1480409Notes

Reaction equation

HRID 1480409 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([OH:11])=O)[O:4][N:3]=1.[NH2:12][CH2:13][CH2:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH2:16]1>>[OH:1][C:2]1[CH:6]=[C:5]([CH2:7][CH2:8][C:9]([NH:12][CH2:13][CH2:14][CH:15]2[CH2:16][CH2:17][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:19][CH2:20]2)=[O:11])[O:4][N:3]=1

Participants

3

Reactant 2

HCID 1514258tert-Butyl 4-(2-aminoethyl)piperidine-1-carboxylateHCID 1785253353-(3-Hydroxy-5-isoxazolyl)propanoic acid

Product 1

HCID 178451875HCID 178451875, compound

Procedure

The title compound was prepared from commercially available 3-(3-hydroxyisoxazol-5-yl)propanoic acid and tert-butyl 4-(2-aminoethyl)piperidine-1-carboxylate analogously to Example 21 (step 2);

Sources & evidence

ORD record
ord-22040b450b6140b5b4cdbf91c22932c9
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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