2-Oxo-2,3-dihydro-1,3-oxazole-4-carboxylic acid → 3,5-Dichlorobenzyl 4-(2-(N-methyl-2-oxo-2,3-dihydrooxazole-4-carboxamido)ethyl)piperidine-1-carboxylate
Reaction equation
[O:1]=[C:2]1[NH:6][C:5]([C:7]([OH:9])=O)=[CH:4][O:3]1.[CH3:10][NH:11][CH2:12][CH2:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][CH2:23][C:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[C:26]([Cl:31])[CH:25]=2)=[O:21])[CH2:16][CH2:15]1>>[CH3:10][N:11]([CH2:12][CH2:13][CH:14]1[CH2:15][CH2:16][N:17]([C:20]([O:22][CH2:23][C:24]2[CH:25]=[C:26]([Cl:31])[CH:27]=[C:28]([Cl:30])[CH:29]=2)=[O:21])[CH2:18][CH2:19]1)[C:7]([C:5]1[NH:6][C:2](=[O:1])[O:3][CH:4]=1)=[O:9]Participants
3
Procedure
The title compound was prepared from 2-oxo-2,3-dihydrooxazole-4-carboxylic acid (step 1) and 3,5-dichlorobenzyl 4-(2-(methylamino)ethyl)piperidine-1-carboxylate (Example 1, step 3) analogously to Example 15 step 3;
Sources & evidence
- ORD record
- ord-9a4e99f00b8440d79ae39a851394b7ac
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09409895B2
Reaction notes
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