Potassium 5-carboxytetrazol-1-ide → 3,5-Dichlorobenzyl 4-(2-(N-methyl-2H-tetrazole-5-carboxamido)ethyl)piperidine-1-carboxylate

HRID 1480419Notes

Reaction equation

HRID 1480419 reaction equation
[C:1]([C:4]1[N-:8][N:7]=[N:6][N:5]=1)(O)=[O:2].[K+].[CH3:10][NH:11][CH2:12][CH2:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][CH2:23][C:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[C:26]([Cl:31])[CH:25]=2)=[O:21])[CH2:16][CH2:15]1>>[CH3:10][N:11]([CH2:12][CH2:13][CH:14]1[CH2:15][CH2:16][N:17]([C:20]([O:22][CH2:23][C:24]2[CH:25]=[C:26]([Cl:31])[CH:27]=[C:28]([Cl:30])[CH:29]=2)=[O:21])[CH2:18][CH2:19]1)[C:1]([C:4]1[N:8]=[N:7][NH:6][N:5]=1)=[O:2]

Participants

3

Reactant 2

HCID 13596208Potassium 5-carboxytetrazol-1-ideHCID 86722625HCID 86722625, compound

Product 1

HCID 762846763,5-Dichlorobenzyl 4-(2-(N-methyl-2H-tetrazole-5-carboxamido)ethyl)piperidine-1-carboxylate

Procedure

The title compound was prepared from potassium 5-carboxytetrazol-1-ide and 3,5-dichlorobenzyl 4-(2-(methylamino)ethyl)piperidine-1-carboxylate (Example 1 step 3) analogously to Example 16;

Sources & evidence

ORD record
ord-6654acaf999f4713bc8ac8cebc137b6b
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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