Trifluoroacetic acid → HCID 90218727, compound

Participants

Reaction Steps

To 3,5-dichlorobenzyl 4-(3-(tert-butoxycarbonylamino)propyl)piperazine-1-carboxylate (step 1) (438 mg, 0.981 mmol) in DCM (6 ml) was added TFA (3 ml, 38.9 mmol). The resulting solution was stirred for 1 hr and then concentrated under reduced pressure. The residue was basified with saturated sodium bicarbonate solution (50 ml) and extracted with EtOAc (2×100 ml). The combined extracts were dried (MgSO4) and concentrated to give 3,5-dichlorobenzyl 4-(3-aminopropyl)piperazine-1-carboxylate as a tan crystalline solid;

Provenance & Evidence