TRANS-2,4-DICHLOROCINNAMIC ACID → HCID 86722672, compound

HRID 1480446Notes

Reaction equation

HRID 1480446 reaction equation
[C:1]([O:7][CH2:8][N:9]1[CH:13]=[C:12]([CH2:14][CH2:15][CH2:16][C:17](=[O:25])[NH:18][CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[N:11]=[N:10]1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[Cl:26][C:27]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:28]=1/[CH:34]=[CH:35]/[C:36](O)=[O:37]>>[C:1]([O:7][CH2:8][N:9]1[CH:13]=[C:12]([CH2:14][CH2:15][CH2:16][C:17]([NH:18][CH:19]2[CH2:20][CH2:21][N:22]([C:36](=[O:37])/[CH:35]=[CH:34]/[C:28]3[CH:29]=[CH:30][C:31]([Cl:33])=[CH:32][C:27]=3[Cl:26])[CH2:23][CH2:24]2)=[O:25])[N:11]=[N:10]1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 688026TRANS-2,4-DICHLOROCINNAMIC ACIDHCID 86722666HCID 86722666, compound

Product 1

HCID 86722672HCID 86722672, compound

Procedure

The title compound was prepared from (4-(4-oxo-4-(piperidin-4-ylamino)butyl)-1H-1,2,3-triazol-1-yl)methyl pivalate (Example 37, step 5) (200 mg, 0.516 mmol) and (E)-3-(2,4-dichlorophenyl)acrylic acid (step 1) analogously to Example 38 step 1.

Sources & evidence

ORD record
ord-63e8c038b00a47d48d0fefa9269cb32e
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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