3-(2,4-Dichlorophenyl)propanoic acid → HCID 178520553, compound

HRID 1480451Notes

Reaction equation

HRID 1480451 reaction equation
C(OC[N:9]1[CH:13]=[C:12]([CH2:14][CH2:15][CH2:16][C:17](=[O:25])[NH:18][CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[N:11]=[N:10]1)(=O)C(C)(C)C.[Cl:26][C:27]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:28]=1[CH2:34][CH2:35][C:36](O)=[O:37]>>[Cl:26][C:27]1[CH:32]=[C:31]([Cl:33])[CH:30]=[CH:29][C:28]=1[CH2:34][CH2:35][C:36]([N:22]1[CH2:21][CH2:20][CH:19]([NH:18][C:17](=[O:25])[CH2:16][CH2:15][CH2:14][C:12]2[N:11]=[N:10][NH:9][CH:13]=2)[CH2:24][CH2:23]1)=[O:37]

Participants

3

Reactant 2

HCID 27409153-(2,4-Dichlorophenyl)propanoic acidHCID 86722666HCID 86722666, compound

Product 1

HCID 178520553HCID 178520553, compound

Procedure

The title compound was prepared from (4-(4-oxo-4-(piperidin-4-ylamino)butyl)-1H-1,2,3-triazol-1-yl)methyl pivalate (Example 37, step 5) (200 mg, 0.516 mmol) and commercially available 3-(2,4-dichlorophenyl)propanoic acid (Fisher) (113 mg, 0.516 mmol) analogously to Example 38, steps 1 and 2;

Sources & evidence

ORD record
ord-d18959649e26453fa62573054830ee26
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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