反应详情

A reaction mixture comprising of N-(8-azabicyclo[3.2.1]octan-3-yl)-4-(1H-1,2,3-triazol-4-yl)butanamide (294 mg, 1.116 mmol), 3,5-dichlorobenzyl carbonochloridate (267 mg, 1.116 mmol) and sodium hydroxide (5.58 ml, 112 mmol) in DCM (3.7 ml) was stirred at room temperature for 18 hours. The reaction mixture was separated and the organic portion was dried over MgSO4, filtered and concentrated under reduced pressure. Further purification was carried out using preparative LC-MS and the resulting product fractions were concentrated under reduced pressure to give aqueous solutions which were extracted with ethyl acetate. The organic extracts were dried over MgSO4, filtered and concentrated under reduced pressure to afford the title compound.

1. customThe reaction mixture was separated
2. dry with materialthe organic portion was dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated under reduced pressure
5. customFurther purification
6. concentrationthe resulting product fractions were concentrated under reduced pressure
7. customto give aqueous solutions which
8. extractionwere extracted with ethyl acetate
9. dry with materialThe organic extracts were dried over MgSO4
10. filtrationfiltered
11. concentrationconcentrated under reduced pressure