Thionyl Chloride → HCID 10331694, compound

HRID 1480465Notes

Reaction equation

HRID 1480465 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11](O)=[O:12])=[CH:5][CH:4]=1.S(Cl)([Cl:18])=O>>[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([Cl:18])=[O:12])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 35887363-(4-(Trifluoromethyl)phenyl)propionic Acid

Product 1

HCID 10331694HCID 10331694, compound

Procedure

A stirred solution of 3-(4-(trifluoromethyl)phenyl)propanoic acid (500 mg, 2.292 mmol) in thionyl chloride was allowed to reflux for 2 hours and concentrated under reduced pressure to afford the crude title product.

Workup

  1. temperatureto reflux for 2 hours
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-efd2aaddb9054004b01a9bbc4344b84a
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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