Sodium Hydroxide → HCID 86722693, compound

HRID 1480473Notes

Reaction equation

HRID 1480473 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH2:3][CH2:2]1.[OH-].[Na+].[C:14](Cl)(=[O:25])[O:15][CH2:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([Cl:24])[CH:18]=1>C(Cl)Cl>[Cl:23][C:21]1[CH:22]=[C:17]([CH:18]=[C:19]([Cl:24])[CH:20]=1)[CH2:16][O:15][C:14]([N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH2:3][CH2:2]1)=[O:25]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 15208063-(Piperidin-4-yl)propanoic acidHCID 133055323,5-Dichlorobenzyl Chloroformate

Product 1

HCID 86722693HCID 86722693, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 3-piperidin-4-yl-propionic acid (1 g, 6.36 mmol) in DCM (20 ml) was added 2M NaOH (9.54 ml, 19.08 mmol) to give a colorless biphasic solution. 3,5-Dichlorobenzyl carbono-chloridate (1.523 g, 6.36 mmol) was added to the reaction mixture and this was stirred at RT for 2 hrs. The mixture was extracted with DCM (2×50 ml), and the organics were dried (MgSO4) and concentrated to give the product as a white solid.

Workup

  1. customto give a colorless biphasic solution
  2. extractionThe mixture was extracted with DCM (2×50 ml)
  3. dry with materialthe organics were dried (MgSO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-42fae9e0646e44daaffff14a907f9a21
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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