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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1480482Generated: October 31, 2026

Hydrochloric Acid → HCID 90218734, compound

https://huagongshe.com/reaction/1480482

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant1,4-DioxaneHCID 31275—
ReactantHCID 90218961HCID 90218961—
SolventDichloromethaneHCID 6344—
ProductHCID 90218734HCID 90218734—

Reaction Steps

To a stirred solution of 3-methyl-5-(trifluoromethyl)benzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate (237 mg, 0.569 mmol) in DCM (5 ml) at RT under nitrogen was added 4M HCl in Dioxane (1.423 ml, 5.69 mmol) and the reaction mixture stirred at RT for 3 hours. The reaction mixture was concentrated under reduced pressure to afford the title product as the hydrochloride salt;

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09409895B2
Source datasetuspto-grants-2016_08
ORD IDord-781d690020924f9dba213c486a117d8d
Source noteuspto-grants-2016_08