Thionyl Chloride → 5-(1H-1,2,3-triazol-4-yl)pentanoyl chloride

Participants

Reaction Steps

To a suspension of 5-(1H-1,2,3-triazol-4-yl)pentanoic acid (Example 20, step 3) (100 mg, 0.591 mmol) in DCM (5 mL) at RT under nitrogen was added thionyl chloride (0.518 mL, 7.09 mmol). The reaction mixture was stirred at rt for 2 hours and concentrated under reduced pressure to afford the title product.

Provenance & Evidence