Thionyl Chloride → HCID 178521139, compound

HRID 1480490Notes

Reaction equation

HRID 1480490 reaction equation
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][C:8]([OH:10])=O)[N:3]=[N:2]1.S(Cl)([Cl:13])=O>C(Cl)Cl>[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][C:8]([Cl:13])=[O:10])[N:3]=[N:2]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178525362HCID 178525362, compound

Product 1

HCID 178521139HCID 178521139, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-(1H-1,2,3-triazol-4-yl)propanoic acid (Example 19, step 2) (100 mg, 0.709 mmol) in DCM (5 mL) at RT under nitrogen was added thionyl chloride (0.621 mL, 8.50 mmol) and the reaction mixture stirred for 2 hours. The reaction mixture was concentrated under reduced pressure to afford the title product.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a54b04e4bead41eea60d2d15797dc4fb
Source dataset
uspto-grants-2016_08
Patent number
US09409895B2

Reaction notes

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