Formaldehyde → HCID 86718560, compound

Participants

Reaction Steps

tert-Butylamine (16.1 g, 0.22 mol) was added to a mixture of 2,4-dibromophenol (11.1 g, 0.044 mol) and paraformaldehyde (6.61 g, 0.22 mol) in 2-propanol (110 mL) and the reaction mixture refluxed under nitrogen overnight. The cooled reaction mixture was filtered and the wet cake was rinsed with 2-propanol. The wet cake was dried by suction to give 6,8-dibromo-3-(tert-butyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine (12.66 g, 82.8% yield) as a solid.

Provenance & Evidence