5-Chlorothiophene-2-boronic acid → HCID 86718563, compound

HRID 1480609Notes

Reaction equation

HRID 1480609 reaction equation
Br[C:2]1[C:11]2[O:10]C[N:8]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:7][C:6]=2[CH:5]=[C:4]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:3]=1.[Cl:20][C:21]1[S:25][C:24](B(O)O)=[CH:23][CH:22]=1>>[ClH:20].[C:16]([C:4]1[CH:3]=[C:2]([C:24]2[S:25][C:21]([Cl:20])=[CH:22][CH:23]=2)[C:11]([OH:10])=[C:6]([CH2:7][NH:8][C:12]([CH3:13])([CH3:14])[CH3:15])[CH:5]=1)([CH3:17])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 27343245-Chlorothiophene-2-boronic acidHCID 867185598-bromo-3,6-di-tert-butyl-3,4-dihydro-2H-benzo[e][1,3]oxazine2×

Product 1

HCID 86718563HCID 86718563, compound

Procedure

The title compound was prepared as a white solid using the procedure described in Example 1 from 8-bromo-3,6-di-tert-butyl-3,4-dihydro-2H-benzo[e][1,3]oxazine (Intermediate 1) and 5-chlorothiophene-2-boronic acid [purchased from Frontier Scientific].

Sources & evidence

ORD record
ord-fdb4b26ee7254cb280f23bfb520917c3
Source dataset
uspto-grants-2016_08
Patent number
US09409893B2

Reaction notes

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