Formaldehyde → HCID 75202150, compound

Participants

Reaction Steps

4-(tert-Butyl)-2-((tert-butylamino)methyl)-6-(6-(trifluoromethyl)pyridin-3-yl)phenol (2.00 g, 5.26 mmol) was added to a 37% aqueous solution of formaldehyde (0.47 mL, 5.78 mmol) in THF (6 mL) and the reaction mixture stirred at room temperature for 16 hours. The solvent was removed under reduced pressure and the solid was recrystallized by heating 1.1 g of product in methanol (10 mL) then cooling to room temperature to yield a first crop of 3,6-di-tert-butyl-8-(6-(trifluoromethyl)pyridin-3-yl)-3,4-dihydro-2H-benzo[e][1,3]oxazine (588 mg, 29%) as a white crystalline solid.

Provenance & Evidence