HCID 89995996, compound → HCID 89996159, compound

HRID 1480769Notes

Reaction equation

HRID 1480769 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]2[CH:10]=[N:11][N:12]([CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[CH:13]=2)[CH:6]=[CH:5][C:4]=1[NH:23][CH:24]=O.[CH:26]1([NH:32][C:33]2[C:38]3[N:39]=C(S(C)(=O)=O)[N:41]=[CH:42][C:37]=3[CH:36]=[CH:35][N:34]=2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[CH:26]1([NH:32][C:33]2[C:38]3[N:39]=[C:24]([NH:23][C:4]4[CH:5]=[CH:6][C:7]([C:9]5[CH:10]=[N:11][N:12]([CH2:14][CH2:15][N:16]6[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]6)[CH:13]=5)=[CH:8][C:3]=4[O:2][CH3:1])[N:41]=[CH:42][C:37]=3[CH:36]=[CH:35][N:34]=2)[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 89995996HCID 89995996, compoundHCID 90000823HCID 90000823, compound

Product 1

HCID 89996159HCID 89996159, compoundYield 48%

Procedure

The title compound was prepared according to Example 40 above using N-(2-methoxy-4-(1-(2-(4-methylpiperazin-1-yl)ethyl)-1H-pyrazol-4-yl)phenyl)formamide (Preparation 61) and N-cyclohexyl-2-(methylsulfonyl)pyrido[3,4-d]pyrimidin-8-amine (Preparation 44). The residue was purified by silica gel column chromatography eluting with 0 to 15% MeOH in DCM to give the title compound (51 mg, 48%).

Workup

  1. customThe title compound was prepared
  2. customThe residue was purified by silica gel column chromatography
  3. washeluting with 0 to 15% MeOH in DCM

Sources & evidence

ORD record
ord-99fe3a6eafe74ac48d2d2f783445597c
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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