HCID 68290880, compound → HCID 89996160, compound

HRID 1480789Notes

Reaction equation

HRID 1480789 reaction equation
FC(F)(F)S(O[C:7]1[N:8]=[CH:9][C:10]2[C:15]([CH:16]=1)=[C:14]([NH:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[N:13]=[CH:12][CH:11]=2)(=O)=O.[CH3:26][O:27][C:28]1[CH:34]=[C:33]([C:35]2[CH:36]=[N:37][N:38]([CH3:40])[CH:39]=2)[CH:32]=[CH:31][C:29]=1[NH2:30]>>[CH:18]1([NH:17][C:14]2[C:15]3[C:10](=[CH:9][N:8]=[C:7]([NH:30][C:29]4[CH:31]=[CH:32][C:33]([C:35]5[CH:36]=[N:37][N:38]([CH3:40])[CH:39]=5)=[CH:34][C:28]=4[O:27][CH3:26])[CH:16]=3)[CH:11]=[CH:12][N:13]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 68290880HCID 68290880, compoundHCID 89996129HCID 89996129, compound

Product 1

HCID 89996160HCID 89996160, compound

Procedure

The title compound was prepared according to Method 6 (Example 103) using 5-(cyclohexylamino)-2,6-naphthyridin-3-yl trifluoromethanesulfonate (Preparation 93) and 2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)aniline (Preparation 19) for 18 hours. The residue was purified using silica gel column chromatography eluting with 0-10% MeOH in DCM.

Workup

  1. customfor 18 hours
  2. customThe residue was purified
  3. washeluting with 0-10% MeOH in DCM

Sources & evidence

ORD record
ord-c13eaa50e44f4f469b63e501946a8bd7
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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