(Pyridin-4-yl)boronic acid → HCID 90001385, compound

HRID 1480794Notes

Reaction equation

HRID 1480794 reaction equation
Cl[C:2]1[C:7]2[N:8]=[C:9]([NH:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=4)=[CH:15][C:14]=3[O:25][CH3:26])[N:10]=[CH:11][C:6]=2[CH:5]=[CH:4][N:3]=1.[N:27]1[CH:32]=[CH:31][C:30]([B:33]([OH:35])[OH:34])=[CH:29][CH:28]=1>>[N:27]1[CH:32]=[CH:31][C:30]([B:33]([OH:35])[OH:34])=[CH:29][CH:28]=1.[CH3:26][O:25][C:14]1[CH:15]=[C:16]([C:19]2[CH:20]=[N:21][N:22]([CH3:24])[CH:23]=2)[CH:17]=[CH:18][C:13]=1[NH:12][C:9]1[N:10]=[CH:11][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([C:30]3[CH:31]=[CH:32][N:27]=[CH:28][CH:29]=3)[C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 89995981HCID 89995981, compound

Product 1

HCID 90001385HCID 90001385, compound

Procedure

The title compound was prepared according to the method described for Example 208 using 8-Chloro-N-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidin-2-amine (Example 94) and pyridine-4-boronic acid for 30 minutes at each of 100° C., 110° C., 120° C. and 130° C.

Workup

  1. customof 100° C.
  2. custom110° C., 120° C. and 130° C.

Sources & evidence

ORD record
ord-78197b0e829646c7a64b789c19715dc2
Source dataset
uspto-grants-2016_08
Patent number
US09409907B2

Reaction notes

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