反应详情

A solution of 5-bromo-2-(methylthio)pyrimidine-4-carboxylic acid (7.64 g, 30.7 mmol) in MeOH (60 mL) was treated with sulfuric acid (2 mL) and boiled for 24 hours. The mixture was poured onto ice water and extracted with DCM. The DCM phase was washed with saturated aqueous sodium hydrogen carbonate solution, dried and evaporated to give the title compound (6.42 g, 80%).

1. additionThe mixture was poured onto ice water
2. extractionextracted with DCM
3. washThe DCM phase was washed with saturated aqueous sodium hydrogen carbonate solution
4. customdried
5. customevaporated